Nolvadex-D by AstraZeneca 20mg x 30 tablets



  • Ingredient: Tamoxifen Citrate
  • As known as: Nolvadex, Nolvadex-D
  • Content: 20mg
  • Packing Quantity: 30
  • Manufacturer: AstraZeneca (UK)

Mode of Action: Nolvadex anti tumor, anti estrogen agent. Competitively inhibits estrogen receptors in the target organs & tumors derived from these bodies. The result is a complex (drug-receptor cofactor transfer), which, after translocation into the nucleus of cells prevents hypertrophy, estrogen dependent regulation. Has anti gonadotropnym properties, inhibits the synthesis of Pg in the tumor tissue. Slow the progression of the tumor estrogen stimulated. The ability to block estrogen may persist for several weeks after a single dose. In addition, tamoxifen may cause ovulation in women in its absence, by stimulating the release of GnRH from the hypothalamus that stimulates the release of pituitary gonadotropins. In men with oligospermia increases the focus of LH & FSH, testosterone & estrogen in the blood serum. Tamoxifen & some of its metabolites (4-hydroxy tamoxifen) are potent inhibitors of the mixed function oxidases of the cytochrome P450 of the liver, but the clinical significance of these effects was determined.

Interaction: Enhances the effect of indirect anticoagulants requires careful monitoring for dose adjustment of anticoagulants. Cytotoxic agents increase the risk of thrombosis. Allopurinol promotes the development of hepatotoxic effects. The combined use of tamoxifen (Nolvadex) & tegafur can cause chronic active hepatitis & cirrhosis of the liver. Concomitant use of tamoxifen with other hormonal drugs especially estrogen-contraceptives leads to a weakening of the specific effect of both drugs. Drugs that reduce the excretion of Ca2 + (e.g. number of thiazide diuretics) may increase the risk of hypercalcemia. Antacid, H2 blockers of histamine receptors & doctor recommend that reduce gastric acidity may cause premature dissolution, & loss of the protective effect of Valium pills. The interval between tamoxifen & these drugs should be 1-2 hours

Dosage & administration: Usually set individually depending on the evidence. Doctor says treatment for a long time until disease progression, as effect is maintained only with the constant use, if necessary, used in combination with radiation therapy & cytostatic. Nolvadex should be taken without chewing with some fluid in one goes in the morning or sharing the required dose for 2 doses, morning & evening.

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